Menhaden fish oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures.

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Menhaden fish oil improves spatial memory in rat pups following recurrent pentylenetetrazole-induced seizures.
出版類型SCI(Sciences Citation Index)
出版年度2006
AuthorsChih-Cheng Chen, 陳志誠, Hso-Chi Chaung 莊秀琪, Mei-Yung Chung 鍾美勇, & Li-Tung Huang 黃立同
開始頁516
頁數5
出版日期2006 / 5
其他編號0000
中文摘要

This study investigated the effects of two supplementary dietary oils (fish oil and corn oil) as parts of isocaloric/isoproteic diets
on growth, brain fatty acid composition, and behavior in rat pups with recurrent seizures. Recurrent seizures were induced by
injecting rat pups with pentylenetetrazole (PTZ) between P10 (10 days of age) and P14. Either menhaden fish oil (FO) or corn
oil (CO) was given as supplemental dietary oil throughout the experiment from P3 to P40. We assessed the effects of the two supplemental
dietary oils on spatial memory, histomorphology, and fatty acid composition of brain tissue at the end of the study on
P40. Rats that received dietary FO performed significantly better in the Morris water maze, a test used to examine spatial performance
in rats; the FO group had significantly shorter escape latencies (P = 0.041) during the escape test. Compared with the CO
group, the FO group stayed a longer time (P = 0.015) and swam a longer distance (P = 0.033) in the target quadrant in the spatial
probe test. The FO group had significantly higher brain docosahexaenoic acid (P 6 0.01) and significantly lower brain C20:3 n-6 and
C20:4 n-6 (P < 0.01 and P = 0.031) levels compared with the CO group, but the two groups did not differ significantly with respect
to neuronal cell loss in the histomorphology study. This study demonstrated that, compared with CO, FO is better in improving
spatial memory in rats following recurrent PTZ-induced seizures.

期刊名稱Epilepsy Behav.
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