AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration
出版類型SCI(Sciences Citation Index)
出版年度2008
AuthorsWen-Ling Shih, 施玟玲, & Liao Ming-Huei 廖明輝
開始頁202
頁數15
出版日期2008 / 11
其他編號0000
中文摘要

We have previously shown that AMF/PGI induces hepatoma cell migration through the induction of MMP-3. This
work investigates how AMF/PGI activates the MMP-3 gene. We demonstrated that AMF/PGI transactivates the
MMP-3 gene promoter through AP-1. The transactivation and induction of cell migration effect of AMF/PGI directly correlates
with its enzymatic activity. Various analyses showed that AMF/PGI stimulated the Src-RhoA-PI3-kinase signaling
pathway, and these three signaling molecules could form a complex. Our results demonstrate a new mechanism of AMF/
PGI-induced cell migration and a link between Src-RhoA-PI3-kinase, AP-1, MMP-3 and hepatoma cell migration.
 2008 Elsevier Ireland Ltd. All rights reserved.

期刊名稱Cancer Letters
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