Induction of hepatoma cells migration by phosphoglucose isomerase / autocrine motility factor through the upregulation of matrix metalloproteinase-3.

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Induction of hepatoma cells migration by phosphoglucose isomerase / autocrine motility factor through the upregulation of matrix metalloproteinase-3.
出版類型SCI(Sciences Citation Index)
出版年度2004
AuthorsWen-Ling Shih, 施玟玲, & Liao Ming-Huei 廖明輝
開始頁76
頁數6
出版日期2004 / 1
其他編號0000
中文摘要

Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and
fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis. Presently,
we demonstrate that exogenous PGI/AMF stimulates the migration of Huh7 and HepG2 hepatoma cells, but not Hep3B cells.
Inhibition of PGI/AMF by PGI/AMF specific inhibitor 5-phospho-D-arabinonate markedly repressed the cellular migration. RTPCR
was used to examine the expression profile of matrix metalloproteinases (MMPs). MMP-3 transcripts, protein level, and
secreted form were significantly upregulated in PGI/AMF-treated Huh7 and HepG2 cells, but not in Hep3B cells. MMP-3 inhibition
abolished the PGI/AMF-induced cell motility. The observations are consistent with a downstream mediation role of MMP-3 in PGI/
AMF-stimulated tumor cell metastasis.
 2003 Elsevier Inc. All rights reserved.

期刊名稱Biochemical and Biophysical Research Communications
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