ARV-induced apoptosis related to tissue injury.

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題ARV-induced apoptosis related to tissue injury.
出版類型SCI(Sciences Citation Index)
AuthorsWen-Ling Shih, 施玟玲, & Hung-Jen Liu 劉宏仁
出版日期2007 / 4

Apoptosis plays an important role in pathogenesis of many viral infections. Infection of chicken with avian
reovirus S1133 causes tissue injury related to virus-induced apoptosis. To determine whether avian reovirus
(ARV) induced apoptosis in chicken tissues, six 3-week-old specific pathogen freeWhite Leghorn chicks were
inoculated with ARV S1133. Tissues were dual-labelled for the simultaneous detection of viral antigen and
apoptotic cells. DNA laddering was detected in ARV-infected but not mock-infected chicken tissues. Duallabelling
assay revealed that the majority of antigen-expressing cells were not apoptotic. Surprisingly, some
apoptotic but non-antigen-expressing cells were frequently located in the vicinity of antigen-expressing cells.
Syncytium formation in ARV-infected chicken tissues undergoing apoptosis was apparent, suggesting a
correlation between virus replication and apoptosis in chicken tissues.

期刊名稱Avian Pathology
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