Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Pathogenesis

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Pathogenesis
出版類型SCI(Sciences Citation Index)
AuthorsChun-Yen Chu, 朱純燕
出版日期2011 / 6

Innate immune response is important for viral clearance during influenza virus infection. Galectin-1, which belongs to S-type lectins, contains a conserved carbohydrate recognition domain that recognizes galactose-containing oligosaccharides. As the envelope proteins of influenza virus are highly glycosylated, we studied the role of galectin-1 in influenza virus infection in vitro and in mice. We found that galectin-1 was upregulated in the lung of mice during influenza virus infection. There was a positive correlation between galectin-1 levels and viral loads during the acute phase of viral infection. Cells treated with recombinant human galectin-1 generated lower viral yields after influenza virus infection. Galectin-1 could directly bind to the envelope.

期刊名稱Journal of Virology
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