Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model

in Foreign journal (AHCI), 國外期刊(AHCI)
標題Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model
出版類型國外期刊(AHCI)
出版年度2009
AuthorsJiunn-Jye Sheu, 許俊傑, Chun-Man Yuen 袁俊文, Cheuk-Kwan Sun 孫灼均, Li-Teh Chang 張立德, Chia-Hung Yen 顏嘉宏, Chiang-Hua Chiang 江強華, Sheung-Fat Ko 高長發, Sung-Nan Pei 裴松南, Sarah Chua 蔡慧玲, Anuj Bhasin A. B., Chiung-Jen Wu 吳炯仁, & Hon-Kan Yip 葉漢根
開始頁221
頁數13
出版日期2009 / 4
其他編號0000
中文摘要

This study investigated six-month angiographic results of autologous bone marrow mononuclear cell (BMMNC) transplantation immediately following acute myocardial infarction (AMI) in a mini-pig model.
AMI was induced by left anterior descending artery ligation. Twenty-four mini-pigs were equally divided into group 1 [AMI plus saline injection in infarcted area (IA)], group 2 (AMI plus BMMNC transplantation into non-IA), group 3 (AMI plus BMMNC implantation into IA), and group 4 (sham control). One-week culture BMMNCs (3.0 x 10(7)) were immediately transplanted following AMI induction. Angiographic studies over 6 months demonstrated that mitral regurgitation (MR) was lower in groups 3 and 4 than in groups 1 and 2 (all P < 0.01). Wall motion scores and left ventricular ejection fraction (LVEF) were higher in groups 3 and 4 than in groups 1 and 2 (all P < 0.05) . Collateral circulation was higher in group 3 than in groups 1 and 2 (P < 0.01). The wall thickness of the IA was higher, whereas the heart weight was lower in group 3 than in groups 1 and 2 (all P < 0.01).
Immediate autologous BMMNC transplantation into IA is superior to saline-treated only or BMMNC transplantation into non-IA following AMI for reducing MR and improving LVEF.

期刊名稱International Heart Journal
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