Active component of Danshen (Salvia miltiorrhiza Bunge), tanshinone I, attenuates lung tumorigenesis via inhibitions of VEGF, cyclin A, and cyclin B expressions

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Active component of Danshen (Salvia miltiorrhiza Bunge), tanshinone I, attenuates lung tumorigenesis via inhibitions of VEGF, cyclin A, and cyclin B expressions
出版類型SCI(Sciences Citation Index)
出版年度2013
AuthorsZhi-Sheng Wang, 王, Yi-Hsuan CHEN 陳, Chen-Yu Lee 李鎮宇, Yu-Ching Chou 周, Zhao-Cai L 李, Hsin-Chung Tsai 蔡, Yi-Ling Lin 林, & Chuan-Mu Chen 陳全木
開始頁319247
頁數9
出版日期2013 / 4
其他編號0000
中文摘要

Tanshinone I (T1) and tanshinone II (T2) are the major diterpenes isolated from Danshen (Salvia miltiorrhizaBunge).Three human
lung adenocarcinoma cell lines, A549, CL1-0, and CL1-5, were treated with T1 and T2 for the in vitro antitumor test. Results showed
that T1 was more effective than T2 in inhibiting the growth of lung cancer cells via suppressing the expression of VEGF, Cyclin A,
and Cyclin B proteins in a dose-dependent manner. Moreover, a transgenic mice model of the human vascular endothelial growth
factor-A165 (?????????-??165) gene-induced pulmonary tumor was further treated with T1 for the in vivo lung cancer therapy test. T1
significantly attenuated hVEGF-A165 overexpression to normal levels of the transgenic mice (Tg) that were pretreated with human
monocytic leukemia THP-1 cell-derived conditioned medium (CM). It also suppressed the formation of lung adenocarcinoma
tumors (16.7%) compared with two placebo groups (50% for Tg/Placebo and 83.3% for Tg/CM/Placebo;?? < 0.01). This antitumor
effect is likely to slow the progression of cells through the S and G2/M phases of the cell cycle. Blocking of the tumor-activated
cell cycle pathway may be a critical mechanism for the observed antitumorigenic effects of T1 treatment on vasculogenesis and
angiogenesis.

網址http://www.hindawi.com/journals/ecam/2013/319247/abs/
期刊名稱Evidence-Based Complementary and Alternative Medicine
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