Suppression of hepatitis B virus X protein-mediated tumorigenic effects by ursolic acid

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Suppression of hepatitis B virus X protein-mediated tumorigenic effects by ursolic acid
出版類型SCI(Sciences Citation Index)
出版年度2011
AuthorsHong-Yin Wu, 吳鴻音, Chang 張誌益, 林柏瑋, 尤封陵, Ping-Yuan Lin 林炳源, Liao Ming-Huei 徐睿良, Chia-Hung Yen 顏嘉宏, Liao Ming-Huei 廖明輝, & Wen-Ling Shih 施玟玲
開始頁1713
頁數9
出版日期2011 / 3
其他編號0000
中文摘要

This study investigated the potential effects of natural products ursolic acid (UA) and oleanolic acid (OA) against HBx-mediated tumorigenic activities in vitro and in vivo. HBx transactivated Sp-1 and Smad 3/4 in Huh7 and FL83B hepatocytes and induced cell migration of Huh7 and HepG2. HBx also induced MMP-3 secretion in Huh7 and acted against TGF-β-induced apoptosis in Hep3B. UA almost completely blocked the HBx-mediated effects, while OA had a partial inhibitive effect. Utilization of specific MAPK inhibitors and immunoblotting demonstrated that UA selectively activated MAPK signaling in certain tested cells. Preintraperitoneal injection of UA fully prevented the tumor growth of HBV-containing 2.2.15 cells, while OA-treated mice had smaller tumors than the control group. Our results suggested that UA possesses a hepatoprotective ability and illustrated the evident effects against HBx-mediated tumorigenic activities without toxicity in a mouse model.

期刊名稱Journal of Agricultural and Food Chemistry
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