S100P Expression Is a Novel Prognostic Factor in Hepatocellular Carcinoma and Predicts Survival in Patients with High Tumor Stage or Early Recurrent Tumors

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標題S100P Expression Is a Novel Prognostic Factor in Hepatocellular Carcinoma and Predicts Survival in Patients with High Tumor Stage or Early Recurrent Tumors
出版類型SCI(Sciences Citation Index)
出版年度2013
AuthorsYung- Ming Jeng, 鄭永銘, & Ko-Tung Chang 張格東
開始頁65501
頁數-65501
出版日期2013 / 6
其他編號0000
中文摘要

The calcium-binding protein S100P is expressed in a variety of human cancer cells and is important in cancer cell growth
and invasion. Using differential display, we found S100P is overexpressed in human hepatocellular carcinoma (HCC). We
examined the expression of 305 unifocal, primary HCC tumors using immunohistochemistry. The S100P protein was
expressed in 173 of the 305 (56.7%) HCC tumors. The expression of S100P correlated with female sex (P=0.0162), high
serum a-fetoprotein level (P=0.0001), high tumor grade (P=0.0029), high tumor stage (P=0.0319), the presence of the p53
mutation (P=0.0032), and the absence of the b-catenin mutation (P=0.0489). Patients with HCC tumors that expressed
S100P were more likely to have early tumor recurrence (ETR) (P=0.0189) and lower 5-year survival (P=0.0023). The
multivariate analysis confirmed that S100P expression was an independent prognostic factor in HCC. The combinatorial
analysis showed an additive unfavorable prognostic interaction between S100P expression and the p53 mutation. In
contrast, the b-catenin mutation was associated with better prognosis in both S100P-positive and -negative HCCs.
Furthermore, S100P expression was a predictor of survival in HCC patients with high tumor stage or ETR (P=0.0026 and
P=0.0002, respectively). Our study indicates the expression of the S100P protein is a novel independent predictor for poor
prognosis in HCC, and it is also an unfavorable prognostic predictor in HCC patients with high tumor stage or ETR.

期刊名稱PLoS ONE
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