Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms
出版類型SCI(Sciences Citation Index)
出版年度2014
AuthorsChang, 張誌益, Chang-Hung Chou 周昌弘, Liao Ming-Huei 廖明輝, 陳姿?, Chia-Hsin Cheng 鄭佳欣, R. A., Chung-Pao Tsai 蔡崇寶, 曾心儀, & Hsueh-Ling Cheng 鄭雪玲
開始頁260
頁數13
出版日期2014 / 9
其他編號NSC 99-2313-B-020 -003 -MY3
中文摘要

Pumpkin has been suggested to have antidiabetic effect, but the bioactives involved and molecular mechanisms mediating its hypoglycaemic activity are not clear. This study characterized some of the hypoglycaemic constituents in the crude extract of the Cucurbita moschata stem and investigated the mechanisms of their action. The C. moschata stem extract showed a hypoglycaemic effect in vivo in streptozotocin-induced diabetic mice. Several hypoglycaemic fractions of the extract were identified via cell-based screening, and two of them were confirmed to have hypoglycaemic activities in vivo. Ten compounds were afforded from the 2 fractions. Compounds 9 [(22E,24R)-24-methyl-6β-methoxy-5α-cholesta-7,22-diene-3β,5-diol] and 10 [3β-hydroxy-(22E,24R)-ergosta-5,8,22-trien-7-one] showed an insulin-like activity in normal cells that may be mediated by AMP-activated protein kinase. Compounds 4 (ferulic acid), 8 (syringaresinol) and 9 exhibited an insulin sensitizing and/or insulin substitution function in insulin-resistant cells. Thus, the C. moschata stem contains compounds with potential for managing type 1 or type 2 diabetes.

期刊名稱Journal of Functional Foods
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