The Pharmacokinetics of flumequine in Soft-shelled Turtles (Pelodiscus sinensis) after Oral Administration

in Domestic Conference (poster summary), 國內研討會(摘要海報發表)
標題The Pharmacokinetics of flumequine in Soft-shelled Turtles (Pelodiscus sinensis) after Oral Administration
出版類型國內研討會(摘要海報發表)
出版年度2016
Authors, 葉思妤, & Tsai 蔡清恩
會議名稱105年度春季學術研討會
出版日期May 14 2016 12:0
會議地點嘉義大學
其他編號0000
中文摘要

The flumequine (FLU) is only approved to use in aquatic animals of perciformes and anguilliformes orders in Taiwan. In this study, the pharmacokinetic profile of FLU was investigated in Soft-shelled Turtles (Pelodiscus sinensis) after oral (20 mg/kg b.w.) administration. FLU was administered to 6 soft-shelled turtles via gastric tube. Blood was taken from jugular vein at 0.25, 0.5, 1, 2, 4 and 8 hr after oral administration. The Serum was detected by HPLC with fluorescence detection and the concentration-time curve was described by a non-compartment model. The maximum concentration in the blood(Cmax), maximum high concentration time(Tmax), elimination half-life (t1/2β ), and area under the concentration-time curve (AUC) of Soft-shelled Turtles were 3.02 mg/mL, 0.45 h, 28.95h and 75.03 h‧mg/mL, respectively. The concentration of FLU in serum at 8 hr after oral administration was still above the MIC. It may be showed that the FLU possessed of bacteria inhibitory effect when applied 20 mg/kg by oral administration in Soft-shelled Turtles.

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