The pharmacokinetic of florfenicol in soft-shell turtle

in Domestic Conference (poster summary), 國內研討會(摘要海報發表)
標題The pharmacokinetic of florfenicol in soft-shell turtle
出版類型國內研討會(摘要海報發表)
出版年度2016
Authors, 林嘉敏, & Tsai 蔡清恩
會議名稱105年度春季學術研討會
出版日期May 14 2016 12:0
會議地點嘉義大學
其他編號0000
中文摘要

Florfenicol is a broad spectrum antibacterial, high therapeutic effects and low toxicity of often used in veterinary antibiotic. The pharmacokinetic study of florfenicol in the fields on soft-shelled turtles is rare, thus it is necessary to build the effective treatment dosage and withdraw period for florfenicol application to soft-shelled turtles. In this study, the pharmacokinetic profile of florfenicol was investigated in soft-shelled turtles (Pelodiscus sinensis) after oral (40 mg/kg b.w.) administration. Six soft-shell turtles weighed 511.75 ± 21.98 g were administrated via gastric tube. Blood was taken from jugular vein at 0.25, 0.5, 1, 2, 4, 8 and 12 hr after oral administration. Standard concentrations are 10, 5, 2.5, 1.25, 0.625, and 0.3125μg/mL and detected by HPLC method. Standard curve was obtained, y = 43.865x - 0.6154, which gives r2 = 0.9999, and recovery rate is 86.14-94.89%.The Serum was detected by HPLC with fluorescence detection and the concentration- time curve was described by a non-compartment model. The maximum concentration in the blood(Cmax), maximum high concentration time(Tmax), elimination half-life (t1/2β ) and area under the concentration-time curve (AUC) of Soft-shelled Turtles were 2.85μg / mL, 4h, 0.75h and 11.86 h‧μg/mL, respectively. The results indicated that the florfenicol possessed of bacteria inhibitory effect when applied 40 mg/kg by oral administration in soft-shelled turtles.

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