Depletion of carbadox and its metabolite (quinoxaline-2-carboxylic acid) in pigs following a single dose and multiple in-feed dosing.

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Depletion of carbadox and its metabolite (quinoxaline-2-carboxylic acid) in pigs following a single dose and multiple in-feed dosing.
出版類型SCI(Sciences Citation Index)
出版年度2012
AuthorsCheng-Hsueh Wu, 吳政學, CHUI-SHIANG CHANG 張菊香, & Tsai 蔡清恩
開始頁1990
頁數10
出版日期2012 / 4
其他編號0000
中文摘要

The tissue distribution and residue depletion of carbadox and its metabolites (QCA) were investigated in swine after a single oral dose of 3.5 mg=kg of body weight of carbadox and multiple dose (2 weeks) in-feed (50 ppm) administration. Plasma, muscle, liver, and kidney were sampled pre- and post-treatment and, subsequently, analyzed for carbadox and QCA concentrations using liquid chromatography with tandem mass spectrometry (LC-MS-MS). Carbadox concentration in plasma peaked 2 hr after a single oral dose administration, while QCA concentration was still detectable in liver tissue (2 ng=g) at the fifth week and in kidney tissue (0.9 ng=g) at the sixth week after withdrawal. The volume of distribution (V) of carbadox is 4700t=_2200 mL=kg and areas under the concentration curves (2.36t=_0.86 hr lg=mL) indicated that the drug was adequately distributed throughout the body from the blood of pigs. The slow elimination of the carbadox metabolites suggests a need for long withdrawal periods prior to the use of dosed swine for human consumption.

期刊名稱Journal of Liquid Chromatography & Related Technologies
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