The Pharmacokinetics of Flumequine in Milkfish (Chanos chanos) after oral administration

in Domestic Conference (poster summary), 國內研討會(摘要海報發表)
標題The Pharmacokinetics of Flumequine in Milkfish (Chanos chanos) after oral administration
Authors, 楊沁晏, & Tsai 蔡清恩
出版日期May 14 2016 12:0

The flumequine(FLU) is only approved to use in aquatic animals of perciformes and anguilliformes orders in Taiwan. In this study, the pharmacokinetic profile of flumequine was investigated in Milkfish (Chanos chanos) after oral (20 mg/kg b.w.) administration. FLU was administered to 30 milkfish via gastric tube. Blood was taken from caudal vein or heart at 0.25, 0.5, 1, 2 and 3 hr after oral administration. The serum was detected by HPLC with fluorescence detection and the concentration-time curve was described by a non-compartment model. The maximum concentration in the blood (Cmax), maximum high concentration time (Tmax), elimination half-life (t1/2β), area under the concentration-time curve(AUC), calibration curve, limit of detection , and the recovery rate of Milkfish were 2.2692 mg/mL, 0.35 h, 1.86 h, 1.55 h‧μg/L, y=283.08x-2.2559, 0.054 and 80%, respectively. The concentration of FLU in serum at 3 hr after oral administration remains constantly below MIC. It shows that the concentration of FLU remains constantly below 0.2 μg/mL which is far lesser than the critical level of 0.5 μg/mL when applied 20 mg/kg by oral administration in Milkfish.

校址:912 屏東縣內埔鄉學府路1號 總機:886-8-7703202 傳真:886-8-7740165 系統開發統維護單位:國立屏東科技大學 電算中心 版權所有