Orthoquinone and Naphthalenone Derivatives from Berrya ammonilla and Their Anti-Inflammatory Activity

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Orthoquinone and Naphthalenone Derivatives from Berrya ammonilla and Their Anti-Inflammatory Activity
出版類型SCI(Sciences Citation Index)
出版年度2012
AuthorsSheng-Zehn Yang, 楊勝任
開始頁919
頁數6
出版日期2012 / 1
其他編號0000
中文摘要

A new orthoquinone, berryammone A (1), and
four new naphthalenone derivatives, berryammone
B (2), berryammone C (3), 6-O-methylberryammone
C (4), and 4-O-methylberryammone C
(5), have been isolated from the stem of Berrya
ammonilla, together with eleven known compounds
(6–16). The structures of these new compounds
were determined through spectroscopic
and MS analyses. Among the isolates, compounds1–3, 5, (+)-pinoresinol (6), and betulinic acid (12)
exhibited inhibition (IC50 ? 4.41 μM) of superoxide
anion generation by human neutrophils in response
to formyl-L-methionyl-L-leucyl-L-phenylalanine/
cytochalasin B (fMLP/CB). Compounds 1,
2, and 5 also inhibited fMLP/CB-induced elastase
release with IC50 values ? 3.95 μM.

期刊名稱Planta Med 2012
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