Cancer preventive activities of tea polyphenols

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Cancer preventive activities of tea polyphenols
出版類型SCI(Sciences Citation Index)
AuthorsChung S. Yang, 楊中樞, Huanyu Jin 金環宇, Fei Guan 關菲, Yu-Kuo Chen 陳與國, & Hong Wang 王宏
出版日期2012 / 4

The cancer preventive activities of tea (Camellia Sinensis Theaceae) have been investigated extensively. Green tea polyphenols have been shown to inhibit tumorigenesis in different animal models, including those for cancers of the lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, skin, prostate and mammary glands. Enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis have been shown to be associated with the inhibition of carcinogenesis by tea polyphenols in animals. Many studies in cell lines have demonstrated the modulation of signal transduction and metabolic pathways by (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in green tea. The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated in epidemiological studies. The relationship between tea consumption and cancer risk may become more clear if we could better quantify the tea consumption, adjust for confounding factors and consider genetic polymorphisms of the population. Ongoing human studies on the prevention of prostate, oral, lung, colon, and breast cancers by tea polyphenols are expected to yield more information on this important topic.

期刊名稱Journal of Food and Drug Analysis
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