Baicalein triggers mitochondria-mediated apoptosis and enhances the anti-leukemic effect of vincristine in childhood acute lymphoblastic leukemia CCRF-CEM cells

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Baicalein triggers mitochondria-mediated apoptosis and enhances the anti-leukemic effect of vincristine in childhood acute lymphoblastic leukemia CCRF-CEM cells
出版類型SCI(Sciences Citation Index)
出版年度2013
AuthorsYun-Ju Chen, 陳韻如, Chieh-Shan Wu 吳介山, Jeng-Jer Shieh 謝政哲, Jyh-Horng Wu 吳志鴻, Hsin-Yu Chen 陳欣俞, Ting-Wen Chung 鍾婷雯, Yu-Kuo Chen 陳與國, & Chi-Chen Lin 林季千
開始頁1
頁數18
出版日期2013 / 1
其他編號0000
中文摘要

Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of childhood leukemia, and chemotherapy remains the mainstay therapy. Baicalein is an active flavonoid used in traditional Chinese medicine and has recently been found to have anticancer, anti-inflammatory, and antiallergic properties. This study aims to investigate the molecular apoptotic mechanisms of baicalein in CCRF-CEM leukemic cells and to evaluate the combined therapeutic efficacy of baicalein with several commonly used chemotherapeutic drugs in CCRF-CEM cells. Our results demonstrate that baicalein induces mitochondria-dependent cleavage of caspases-9 and -3 and PARP with concomitant decreases in IAP family proteins, survivin, and XIAP. Furthermore, our results present for the first time that baicalein triggers a convergence of the intrinsic and extrinsic apoptotic pathways via the death receptor-caspase 8-tBid signaling cascade in CCRF-CEM cells. In addition, we also present for the first time that the combination of baicalein and vincristine results in a synergistic therapeutic efficacy. Overall, this combination strategy is recommended for future clinical trials in the treatment of pediatric leukemia owing to baicalein’s beneficial effects in alleviating the vomiting, nausea, and skin rashes caused by chemotherapy.

期刊名稱Evidence-based Complementary and Alternative Medicine
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