Rice bran feruloylated oligosaccharides activate dendritic cells via Toll-like receptor 2 and 4 signaling

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Rice bran feruloylated oligosaccharides activate dendritic cells via Toll-like receptor 2 and 4 signaling
出版類型SCI(Sciences Citation Index)
出版年度2014
AuthorsChi-Chen Lin, 林季千, Hua-Han Chen 陳樺翰, Yu-Kuo Chen 陳與國, Hung-Chia Chang 張弘志, Ping-Yi Lin 林屏沂, I-Horng Pan 潘一紅, Der-Yuan Chen 陳得源, Chuan-Mu Chen 陳全木, & Su-Yi Lin 林素一
開始頁5325
頁數22
出版日期2014 / 4
其他編號0000
中文摘要

This work presents the effects of feruloylated oligosaccharides (FOs) of rice bran on murine bone marrow-derived dendritic cells (BMDCs) and the potential pathway through which the effects are mediated. We found that FOs induced phenotypic maturation of DCs, as shown by the increased expression of CD40, CD80/CD86 and MHC-I/II molecules. FOs efficiently induced maturation of DCs generated from C3H/HeN or C57BL/6 mice with normal toll-like receptor 4 (TLR-4) or TLR-2 but not DCs from mice with mutated TLR4 or TLR2. The mechanism of action of FOs may be mediated by increased phosphorylation of ERK, p38 and JNK mitogen-activated protein kinase (MAPKs) and increased NF-kB activity, which are important signaling molecules downstream of TLR-4 and TLR-2. These data suggest that FOs induce DCs maturation through TLR-4 and/or TLR-2 and that FOs might have potential efficacy against tumor or virus infection or represent a candidate-adjuvant approach for application in immunotherapy and vaccination.

網址http://www.mdpi.com/1420-3049/19/4/5325
期刊名稱Molecules
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