Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis
出版類型SCI(Sciences Citation Index)
出版年度2015
AuthorsYi-Rong Li, 李宜蓉, Der-Yuan Chen 陳得源, Ching-Liang Chu 朱清良, Shiming Li 李世明, Yu-Kuo Chen 陳與國, Wu Chao-Liang 吳昭良, & Chi-Chen Lin 林季千
開始頁1467
頁數11
出版日期2015 / 12
其他編號0000
中文摘要

The aim of this study was to investigate the effect of naringenin (5,7,4'-trihydroxyflavanone), a citrus flavonoid, on dendritic cell (DC) maturation, as well as its potential as a therapeutic agent in a murine model of collagen-induced arthritis (CIA). Naringenin effectively inhibited lipopolysaccharide (LPS)-induced DC maturation as shown by reductions in the production of proinflammatory cytokines/chemokines, the expression of costimulatory molecules and the Ag-specific T cell priming ability of DCs when given at noncytotoxic doses. In addition, the decrease of LPS-induced MAPK and NF-κB signaling activation may contribute to the inhibitory activity of naringenin. In mice with CIA, the oral administration of naringenin ameliorated the severity of arthritis, reduced the levels of anticollagen Type II (CII) IgG and limited the proliferation of T cells, observed as a lower frequency of Th1 and Th17 cells in the spleen after restimulation with CII. In conclusion, this study shows for the first time that naringenin can manipulate the immunostimulatory properties of DCs and thus represents a potential therapeutic for the treatment of rheumatoid arthritis in humans.

網址https://www.sciencedirect.com/science/article/pii/S0955286315001825?via%3Dihub
期刊名稱The Journal of Nutritional Biochemistry
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