Placental transfer of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in Taiwanese mothers in relation to menstrual cycle characteristics

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Placental transfer of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in Taiwanese mothers in relation to menstrual cycle characteristics
出版類型SCI(Sciences Citation Index)
出版年度2007
AuthorsHow-Ran Chao/Hao-Jan Chao, 趙浩然
開始頁259
頁數6
出版日期2007 / 2
其他編號0000
中文摘要

The aim was to determine the body burden of dioxins and polychlorinated biphenyls (PCBs) and whether they are associated with variables influencing reproduction. Our subjects were healthy women (mean age of 29 [SD=4.5]) from central Taiwan. The congeners of dioxins and dioxin-like PCBs in placentas (n=119) were identified using gas chromatography/high resolution mass spectrometry. The median levels of polychlorinated dibenzo-p-dioxins/dibenzofurans and PCBs were 10.2 (geometric mean [GM]: 9.8, 95% confidence interval [95% CI]: 8.8-10.9) and 2.7 (GM: 2.7, 95% CI: 2.3-3.1) pg WHO-TEQ/g lipid, respectively. Total TEQ level in placentas was significantly correlated with mothers' arm circumference (r=0.22, p=0.043). Increased body fat percentage was associated with higher total TEQ level in placentas. After adjustment for maternal age, pre-pregnant body mass index (BMI), and parity, placental dioxin-TEQ level higher in women (age 19 years) with irregular menstrual cycle than in those (age <18 years) with regular menstrual cycle (p=0.032) and placental PCB-TEQ level was higher in women with menstrual cycles longer than 33 days versus less than 33 days (p=0.006). Thus, environmental exposure to dioxins and PCBs may be related to changes in current menstrual cycle characteristics.

期刊名稱Food and Chemical Toxicology
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