Numerical simulation of electrokinetic injection techniques in capillary electrophoresis microchips

in Sciences Citation Index(SCI), 科學引文索引資料庫(SCI)
標題Numerical simulation of electrokinetic injection techniques in capillary electrophoresis microchips
出版類型SCI(Sciences Citation Index)
AuthorsTsai Chien-Hsiung, 蔡建雄, Fu Lung-Ming 楊瑞珍, Tai 戴昌賢, & Fu Lung-Ming 傅龍明
出版日期2005 / 2

The effective design and control of a capillary electrophoresis(CE) microchip requires a thorough understanding of the electrokinetic transport phenomena associated with its microfluidic injection system. The present study utilizes a numerical simulation approach to investigate these electrokinetic transport processes and to study the control parameters of the injection process. Injection systems with a variety of different configurations are designed and tested, including the cross-form, T-form, double-T-form, variable-volume focused flow cross-form, and variable-volume triple-T-form configuration. Each injection system cycles through a predetermined series of steps in which the magnitudes and distributions of the applied electric field are precisely manipulated in order to effectuate a virtual valve. This study investigates the sample leakage effect associated with each of the injection configurations and applies the double-L, pullback, and focusing injection techniques to minimize the sample leakage effect. The injection methods presented in this paper have the exciting potential for use in high-quality
, high-throughput chemical analysis applications and throughout the micro-total-analysis systems field.

期刊名稱Journal of Electrophoresis
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